Small modification, large effect: Diazirine can be installed quickly and simply in the major or minor groove of DNA for efficient photo-cross-linking to proteins (see picture). This method should be suitable for mapping out protein–DNA interactions, in particular those that may be sensitive to steric hindrance.
No takes yet. Share an insight, caveat, or question.
Shigdel et al. (2007) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: