Multi-omics study of molecular and genetic bases of orthostatic hypotension

Figures

• 

  Fig. 1. Characteristics of the study participants

• 

  Fig. 2. Results of individual gene expression assessment and EWAS. A KCNQ1 expression levels in older adults with OH (case group) and older adults without OH (control group). B KIF13A expression levels in older adults with OH (case group) and older adults without OH (control group). C EWAS results (volcano plot): grey—unsignificant sites, blue—significantly hypomethylated sites, red—significantly hypermethylated sites. D EWAS results (Manhattan plot): dotted line represents the significance threshold

• 

  Fig. 3. Locations of CpG sites in the genome. A Annotation of CpG sites by location relative to CpG islands. B Proportion of CpG sites by their location relative to CpG islands among significant EWAS results and on the MethylationEPIC BeadChip. C Annotation of CpG sites by location in the gene. D Proportion of CpG sites by their location relative to the gene among significant EWAS results and on the MethylationEPIC BeadChip

• 

  Fig. 4. Predictive models. A ROC-AUC across 20 runs of cross-validation of the logistic regression and SVC models. B Permutation importance of features included in the SVC model

• 

  Fig. 5. Results of differential gene expression analysis in the case and control groups. A Volcano plot (red dots represent significant genes). B ORA results. C GSEA results

• 

  Fig. 6. Scheme of the study results annotations