Why the study?
Does experimental cardiac hypertrophy alter the levels of phosphate compounds in rat ventricles?
Population
80 control and 45 hypertrophied rats
Comparison
Induction of experimental cardiac hypertrophy… vs Control rats
Design
Preclinical
Authors
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Suggests possible energy reserve impairment in hypertrophy; leaves open whether creatine phosphate depletion contributes to human heart failure.
Does experimental cardiac hypertrophy alter the levels of phosphate compounds in rat ventricles?
Experimental cardiac hypertrophy in rats is associated with decreased ventricular creatine phosphate, suggesting a defect in phosphate-bond energy utilization may contribute to congestive heart failure.
Minton et al. (1960) studied this question.
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