Key result
Longer HO-1 GT repeats linked to ~4-fold higher risk of post-stent angiographic restenosis.
Why the study?
The influence of HO-1 gene promotor GT repeat length polymorphism on restenosis and adverse cardiac events after coronary stenting was unclear.
Does the presence of longer GT repeats in the HO-1 gene promoter increase the risk of angiographic restenosis and adverse cardiac events in patients after coronary stenting?
Population
323 consecutive patients with successful coronary stenting
Comparison
Long (≥26) vs short (<26) GT repeats in HO-1 gene promotor
Design
Cohort study with quantitative coronary angiography
Follow-up
6 months
Authors
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Longer HO-1 GT repeats were associated with post-stent restenosis; leaves open whether genotyping informs clinical decisions.
Cohort (n=323)
Does the presence of longer GT repeats in the HO-1 gene promoter increase the risk of angiographic restenosis and adverse cardiac events in patients after coronary stenting?
Odds Ratio: 3.74 (95% CI 1.61–8.7)
p-value: p=0.002
The length polymorphism of the GT repeat in the HO-1 gene promoter is an independent risk factor for angiographic restenosis and adverse cardiac events after coronary stenting.
Ying Hwa Chen (2003) conducted a cohort in Coronary stenting (n=323). Longer (≥26) GT repeats in HO-1 gene promotor vs. Shorter (<26) GT repeats was evaluated on Angiographic restenosis (OR 3.74, 95% CI 1.61-8.70, p=0.002). Longer (≥26) GT repeats in the HO-1 gene promotor increased the risk of angiographic restenosis after coronary stenting compared to shorter repeats (OR 3.74; 95% CI 1.61-8.70; P=0.002).
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