IN A PREVIOUS communication (1) we reported the results obtained with testosterone therapy in patients with osseous and soft tissue metastases from carcinoma of the breast. The subsequent progress of the group with osseous metastases has been presented elsewhere (3). The present communication gives the subsequent course of the patients with soft tissue disease and also reports a new series of six patients with soft tissue lesions treated with the androgen. S.K., referred to as “Case 1” in the previous report, exhibited a marked regression of the disease in the breast, a disappearance of supraclavicular, cervical and axillary lymph nodes and of skin nodules after receiving 3150 milligrams of testosterone propionate over a period of about two months. She suffered a psychic disturbance two months later and was institutionalized for one month. No androgen therapy was administered during her stay at the institute. She lost 10 pounds during this interval.
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HERRMANN et al. (1946) studied this question.