March 1, 1991Socio-Environmental Systems ModelingOpen Access

Myristoylation of foot-and-mouth disease virus capsid protein precursors is independent of other viral proteins and occurs in both mammalian and insect cells

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Population

Mammalian and insect cells expressing foot-and-mouth disease virus capsid precursor P1-2A and its…

Comparison

Blocking of the myristoylation site or… vs Unmodified FMDV capsid precursor

Design

Preclinical

Authors

GBGraham J. BelshamStatens Serum Institut CACharles C. AbramsThe Pirbright Institute AKAndrew M. Q. KingThe Pirbright Institute

Discussion

Member takes

Implication

Indicates myristoylation of FMDV capsid precursors is host-independent and dispensable for processing; leaves open its role in assembly or infectivity.

Structured PICO

Population

Mammalian and insect cells expressing foot-and-mouth disease virus (FMDV) capsid precursor P1-2A and its amino-terminal cleavage product 1AB from subgenomic cDNA

Intervention

Blocking of the myristoylation site or substitution of the leader protease sequence by an ATG codon

Comparator

Unmodified FMDV capsid precursor

Outcome

Myristoylation and processing of the FMDV capsid precursorsurrogate

Myristoylation of FMDV capsid precursors occurs independently of other viral proteins in both mammalian and insect cells and is not required for efficient processing.

Cite This Study

Belsham et al. (1991) studied this question.

synapsesocial.com/papers/6a821786f10a9fcdd646be01 https://doi.org/10.1099/0022-1317-72-3-747

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Implication

Indicates myristoylation of FMDV capsid precursors is host-independent and dispensable for processing; leaves open its role in assembly or infectivity.

Myristoylation of foot-and-mouth disease virus capsid protein precursors is independent of other viral proteins and occurs in both mammalian and insect cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Myristoylation of foot-and-mouth disease virus capsid protein precursors is independent of other viral proteins and occurs in both mammalian and insect cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider