Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 24, 2020European Journal of ImmunologyOpen Access

CXCR2‐modified CAR‐T cells have enhanced trafficking ability that improves treatment of hepatocellular carcinoma

View Full Paper
Ask AI
Bookmark
Share

Authors

GLGuangna LiuChongqing Technology and Business UniversityHZHongli ZhengZhejiang Sci-Tech UniversityDHDaosheng HuangTsinghua University

Discussion

Loading...

Member takes

Implication

Preclinical study demonstrates enhanced tumor trafficking and efficacy of CXCR2-engineered CAR-T cells in hepatocellular carcinoma, indicating a strategy to improve solid tumor immunotherapy.

Key Points

  • To determine whether modifying CAR-T cells with the chemokine receptor CXCR2 overcomes poor trafficking and improves therapeutic efficacy in hepatocellular carcinoma.
  • Screened chemokine and chemokine receptor expression across human hepatocellular carcinoma tissues, cell lines, and endogenous T cells.
  • Engineered CAR-T cells to express CXCR2 and assessed their in vitro cytotoxicity and migration capacity.
  • Evaluated in vivo trafficking dynamics, intratumoral accumulation, and antitumor control in a xenograft mouse model.
  • CXCR2 ligands were abundantly expressed in human hepatocellular carcinoma tissues and cell lines, while peripheral and tumor-infiltrating T cells lacked CXCR2 expression.
  • CXCR2-modified CAR-T cells maintained cytotoxic function in vitro while exhibiting significantly increased directed migration.
  • In hepatocellular carcinoma xenograft models, CXCR2-expressing CAR-T cells demonstrated accelerated in vivo trafficking, enhanced tumor-specific accumulation, and superior antitumor activity.

Cite This Study

Liu et al. (2020) studied this question.

synapsesocial.com/papers/6a82193d2beaf6c72d8775c2https://doi.org/10.1002/eji.201948457
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma2015 · 759 citations
  2. 2Chemokine CXCL 1 may serve as a potential molecular target for hepatocellular carcinoma2016 · 25 citations
  3. 3Role of chemokine receptors and intestinal epithelial cells in the mucosal inflammation and tolerance2016 · 81 citations
  4. 4Overexpression of CXCL5 mediates neutrophil infiltration and indicates poor prognosis for hepatocellular carcinoma2012 · 360 citations
  5. 5Overexpression of CXCL2 inhibits cell proliferation and promotes apoptosis in hepatocellular carcinoma2018 · 61 citations