In Brief This study aimed to reassess rates of syphilis azithromycin resistance in Dublin. Of the 104 samples, 36 (34.6%) were positive for Treponema pallidum DNA by polymerase chain reaction. Thirty samples were analyzed for A2058G mutation, 29 samples sequenced. Of the 29 samples, 27 (93.1%) had the mutation. Azithromycin cannot be recommended for the treatment of syphilis in Dublin. Dublin continues to have a very high proportion of azithromycin resistant syphilis isolates. Azithromycin cannot be recommended for syphilis treatment in those who have acquired their syphilis in Ireland.
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Muldoon et al. (2012) studied this question.
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