Mechanistic insights into the stereocontrolling non-covalent π interactions in Pd-catalyzed redox-relay Heck arylation reaction

-butyl substituent effects, a plethora of attractive non-covalent π interactions, including CH-π interaction, lone pair-π interaction and T-shaped π-π interaction, are identified to play a key role in enabling high enantioselectivity of this reaction. This work provides mechanistic insights into the comprehensive understanding of this catalytic cascade, and highlights the significant role played by non-covalent π interactions in its enantiocontrol.