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Nanomachines are subject to random thermal and quantum fluctuations that are not captured by traditional thermodynamic theory. A new theoretical investigation offers a step toward a unified nanoscale theory by showing how externally prepared systems (e.g., atoms in an optical cavity or DNA bases in an enzyme reaction) that interact with a nanoscopic device can be a source of nonequilbrium free energy.
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A 2017 study studied this question.
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