Irritative Nystagmus Induced by Intratympanic Injection of Potassium Chloride in Mice.

Introduction: Current treatment of Meniere's disease is limited to prevention of attacks by reducing endolymphatic hydrops. There is no treatment that provides immediate relief during the vertigo episodes. Thus, animal model experiments are needed being conducted to identify curative treatments for Meniere’s disease. Although animal models of endolymphatic hydrops for Meniere's disease exist, there are no animal models in which vertigo can be induced. In the present study, a mouse model was created to induce irritative nystagmus.