The Primary Immunodeficiencies

THE analysis of immunodeficiency diseases depends heavily on an understanding of the normal development and function of cells belonging to the immune system. The two principal types of cells involved in immune responses are T and B cells. They are generated in different microenvironments, develop as separate lineages, and express different kinds of antigen receptors, but they work together in discriminating between self and nonself.T and B cells are not alone in manning host defense, however. By means of their soluble products, lymphokines and antibodies, they recruit macrophages, neutrophils, cosinophils, basophils, mast cells, and natural killer cells to participate . . .