S ummary 5‐Methyltetrahydropteroylglutamic acid was given intravenously to control subjects and to patients with untreated megaloblastic anaemia. The rate of clearance of this substance from the plasma and excretion into the urine after an intravenous dose of 5 μg./kg. of body weight was followed. The rate of clearance was faster in patients with folate deficiency as compared to control subjects. In pernicious anaemia the clearance was either within the normal range or more rapid than normal if there was associated folate deficiency. No support was obtained for the hypothesis that in pernicious anaemia there is a failure to utilize 5‐methylfolate.
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Chanarin et al. (1968) studied this question.
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