Systemic inflammation, as measured by elevated C-reactive protein, is present in degenerative aortic valve stenosis and may be a useful biomarker for monitoring disease progression.
May support CRP monitoring for aortic stenosis progression; hypothesis-generating and requires prospective validation before clinical use.
Degenerative aortic valve stenosis includes a range of disorder severity from mild leaflet thickening without valve obstruction, "aortic sclerosis", to severe calcified aortic stenosis. It is a slowly progressive active process of valve modification similar to atherosclerosis for cardiovascular risk factors, lipoprotein deposition, chronic inflammation, and calcification. Systemic signs of inflammation, as wall and serum C-reactive protein, similar to those found in atherosclerosis, are present in patients with degenerative aortic valve stenosis and may be expression of a common disease, useful in monitoring of stenosis progression.
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Sánchez et al. (2006) studied this question.
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