A novel nonsense mutation (Q[-2]X) in the apoA-I gene causes isolated complete apoA-I deficiency and severe HDL deficiency, which appears to significantly increase the risk of premature atherosclerosis.
No takes yet. Share an insight, caveat, or question.
Rare apoA-I null mutations may accelerate premature CHD; leaves open apoA-I causality and therapeutic targeting.
Ng et al. (1994) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: