Surprisingly, the “unnatural” aglycone analogue 1 (R Ac) of calicheamicin cleaves double-stranded DNA more effectively than the natural ent-1. If the efficiency of this cleavage for the enediyne effector is determined essentially by its configuration, the sequence selectivity of calicheamicin is rooted in the saccharide recognition sector.
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Aiyar et al. (1994) studied this question.
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