Why the study?
Does combination therapy with indapamide and verapamil retard compared to indapamide and amlodipine improve blood pressure and hemodynamic profiles in patients with uncomplicated stage 2 hypertension?
Does combination therapy with indapamide and verapamil retard compared to indapamide and amlodipine improve blood pressure and hemodynamic profiles in patients with uncomplicated stage 2 hypertension?
Indapamide plus verapamil is more effective for patients with diastolic left ventricular dysfunction (DDLV) type I and hyperkinetic circulation, while indapamide plus amlodipine is more effective for DDLV type 2-3 and hypokinetic circulation.
Both combinations normalize circadian BP rhythm in most stage 2 hypertension patients; extends comparative evidence for indapamide-based dual therapy.
54 patients 42-65 years old with uncomplicated hypertension (stage 2) were studied. The 24-hour blood pressure (ВР) monitoring and doppler-echocardiograpy were performed at baseline and after 16 weeks of treatment. Patients were randomized into 2 groups. In the 1st group patients received combination indapamide with verapamil retard, and in 2nd group, combination of indapamide with amlodipine. The circadian rhythm of BP profile was normalized in 83,9 % of patients in 1st group and in 78,6 % of patients in the 2nd group. In the 1st group, the combination therapy is more effective in patients with diastolic left ventricular dysfunction (DDLV) type I, non-dipper profile of circadian rhythm of BP, and with a hyperkinetic type of circulation. In the 2nd group, combination therapy was effective in patients with DDLV type 2-3 and with a hypokinetic type of circulation.
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Bg et al. (2009) studied this question.
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