Clinical practice guideline reports multimodal management algorithms in patients with sinonasal malignancy, highlighting organ-preserving neoadjuvant chemotherapy.
• The CPG provides key recommendations and algorithms for managing SMs, excluding mucosal melanoma and soft-tissue sarcomas. • The guideline covers diagnosis, staging, risk assessment, treatment and disease monitoring. • Technological advancements in treatment with RT are discussed with a special focus on particle therapy. • Surgical indications for open and transnasal endoscopic surgery are provided. • Neoadjuvant chemotherapy in high-grade, locally advanced SMs helps to select subjects for conservative treatments.
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Resteghini et al. (2025) studied this question.
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