Relationship between endometriosis diagnosis, staging, and typology and inflammatory cytokines

This is the authors' abstract. We don't add key points for this paper.

Objective: ). Design: Cross-sectional analysis using data from the Endometriosis, Natural History, Diagnosis, and Outcomes (ENDO) study. Subjects: A total of 395 premenopausal females in Utah, with no prior endometriosis diagnosis, participating in diagnostic or therapeutic gynecologic laparoscopy/laparotomy, 2007-2009. Exposure: Endometriosis diagnosis, staging (minimal, mild, moderate, severe), and typology (superficial endometriosis [SE], deep infiltrating endometriosis [DE], ovarian endometrioma [OE]), determined through postoperative reports and the revised American Society for Reproductive Medicine classification. Main Outcome Measure: Elevated serum cytokine concentrations defined as IL-6 ≥2 pg/mL, IL-8 ≥3 pg/mL, and TNF-α ≥7.5 pg/mL. Adjusted prevalence ratios (aPR) and 95% confidence intervals (CI) were estimated using generalized linear models controlling for age, body mass index (BMI), race/ethnicity, serum cotinine, and reported use of oral hormonal contraception within the past 2 years. Results: or that staging or typology was associated with any of the inflammatory biomarkers. Conclusion: . Our results are in line with several other studies finding null associations between systemic cytokines, measured via blood-derived specimens, and endometriosis. Whether other cardiovascular disease risk biomarkers, including lipoprotein abnormalities, are associated with endometriosis warrants further research.