⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

August 2, 2011Angewandte Chemie

Introducing Lasso Peptides as Molecular Scaffolds for Drug Design: Engineering of an Integrin Antagonist

Thomas A. Knappe Florian Manzenrieder Carlos Mas‐Moruno Uwe Linne Florenz Sasse Horst Kessler Xiulan Xie Mohamed A. Marahiel

View at Publisher

Ask AI

Bookmark

Share

Abstract

Eine Schlinge für Integrine: Lassopeptide sind eine Klasse stabiler bakterieller Peptide, deren einzigartige Merkmale sie vielversprechend für das Wirkstoff-Design machen. Die Übertragung des Epitops des Integrin bindenden Motivs RGD auf die Lassostruktur von Microcin J25 überführt das verknotete Peptid in einen nanomolaren Integrin-Antagonisten (siehe Bild). Künstliche Lassopeptide können also zur Präsentation von Pharmakophoren verwendet werden.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Knappe et al. (2011) studied this question.

synapsesocial.com/papers/6a82472b5a62cdcac13f16ae https://doi.org/10.1002/ange.201102190

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Improving Oral Bioavailability of Peptides by Multiple N‐Methylation: Somatostatin AnaloguesOriginal Research · 2008 · 372 citations
2Engineering Stabilized Vascular Endothelial Growth Factor-A Antagonists: Synthesis, Structural Characterization, and Bioactivity of Grafted Analogues of CyclotidesIn Vitro Study · 2008 · 180 citations
3Systematic Structure-Activity Analysis of Microcin J25Original Research · 2008 · 131 citations
4Microcin J25, from the Macrocyclic to the Lasso Structure: Implications for Biosynthetic, Evolutionary and Biotechnological PerspectivesOriginal Research · 2004 · 82 citations
5Microcin J25 Has a Threaded Sidechain-to-Backbone Ring Structure and Not a Head-to-Tail Cyclized BackboneOriginal Research · 2003 · 270 citations

More related papers

Structure of Antibacterial Peptide Microcin J25: A 21-Residue Lariat Protoknot2003
Structure of Microcin J25, a Peptide Inhibitor of Bacterial RNA Polymerase, is a Lassoed Tail2003
Isolation and Structural Characterization of Capistruin, a Lasso Peptide Predicted from the Genome Sequence of Burkholderia thailandensis E2642008

More from Angewandte Chemie

Biomimetic Molybdenum Chemistry Spanning all Four Molybdopterin Enzyme Families: From Stoichiometric Oxygen Atom Transfer to Catalytic C─H OxidationSun,
Fluxional Monomers Remodel Crystallinity at Low Loadings in Diketopyrrolopyrrole Co‐Thienothiophene Conjugated PolymersSun,