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Stopping aggregation: Carbazole-based cyanine fluorophores bind selectively to the Aβ(1–40) peptide and its aggregates which are responsible for causing Alzheimer's disease. One of these fluorophores, SLOH, exerts a strong inhibitory effect on Aβ(1–40) fibrillogenesis (see scheme) and can pass through the blood-brain barrier making it a potential therapeutic agent for Alzheimer's disease.
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Yang et al. (2011) studied this question.
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