Essential Pharmacokinetic Information for Drug Dosage Decisions: A Concise Visual Presentation in the Drug Label

A critical issue in labeling is to succinctly communicate, in a manner that is readily understandable and actionable, changes in systemic exposure that affect drug dosing. Current practices in labeling make it difficult for prescribers to locate the most important information influencing their dosing decisions. In this report, we propose the use of forest plots for communicating the pharmacokinetic consequences of intrinsic and extrinsic factors in a concise and readily interpretable manner. Clinical Pharmacology & Therapeutics (2011) 90 3, 471–474. doi:10.1038/clpt.2011.149