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January 1, 1972The Journal of AntibioticsOpen Access

The Structure of the Sulfur-Containing Chromophore of Phleomycin, and Chemical Transformation of Phleomycin to Bleomycin

TOMOHISA TAKITA YASUHIKO MURAOKA Akio Fujii Hiroko Itoh Kenji Maeda HAMAO UMEZAWA

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Abstract

Phleomycins were discovered byUMEZAWA eialin1956as antbacterial antibioticsl2) In1962it was found that phleomycins inhibited animaltomors with a high thera-Peuticindex34)In1964IKEKAWA et al reported that phleomycins were effectively SeParatedinto their components by CM-Sephadex C-25 column chromatography5) The components were named phleomycins ABCDlD2EFGHJand K and could be classedin two groups by UV absorptionOneincluded phleomycins C D2and Fand the otherincluded phle0mycins DlEG

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TAKITA et al. (1972) studied this question.

synapsesocial.com/papers/6a8247d82beaf6c72d877e44 https://doi.org/10.7164/antibiotics.25.197

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