February 1, 2007Clinical Cancer Research

Somatic TP53 Mutations Are Relatively Rare among Adrenocortical Cancers with the Frequent 17p13 Loss of Heterozygosity

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Population

36 adrenocortical tumors with 17p13 loss of heterozygosity (LOH) determined by Southern blot

Design

Cohort

Authors

RLRossella LibéCentre National de la Recherche Scientifique LGLionel GroussinUniversité Paris Cité FTFrédérique TissierDélégation Paris 5

Discussion

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Implication

TP53 mutations may identify higher-risk adrenocortical tumors; hypothesis-generating for prognostic use but should not yet change practice.

Structured PICO

Population

36 adrenocortical tumors with 17p13 loss of heterozygosity (LOH) determined by Southern blot

Outcome

Frequency of TP53 somatic inactivating mutations, intragenic LOH (VNTR1 marker), and p53 overexpression, and their clinico-biological correlationssurrogate

TP53 mutations are present in only a minority of adrenocortical tumors with 17p13 LOH, but when present, they are associated with more aggressive tumor characteristics and poorer disease-free survival.

Cite This Study

Libé et al. (2007) studied this question.

synapsesocial.com/papers/6a82534da221e60789ca408e https://doi.org/10.1158/1078-0432.ccr-06-2085

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Implication

TP53 mutations may identify higher-risk adrenocortical tumors; hypothesis-generating for prognostic use but should not yet change practice.

Somatic TP53 Mutations Are Relatively Rare among Adrenocortical Cancers with the Frequent 17p13 Loss of Heterozygosity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Somatic TP53 Mutations Are Relatively Rare among Adrenocortical Cancers with the Frequent 17p13 Loss of Heterozygosity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider