Why the study?
Does direct intramyocardial injection of genes or stem cells cause release of biomarkers of myocardial damage in patients with severe coronary artery disease?
Population
71 patients with 'no-option' severe coronary artery disease.
Comparison
Direct intramyocardial injections of vascular… vs NOGA mapping alone
Design
Cohort
Follow-up
24 hours
Authors
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May reflect procedural effects without acute harm; leaves open standardized biomarker monitoring in future gene/stem cell trials.
Does direct intramyocardial injection of genes or stem cells cause release of biomarkers of myocardial damage in patients with severe coronary artery disease?
Direct intramyocardial injection of genes or stem cells causes a transient, volume-dependent release of cardiac biomarkers without acute clinical complications.
Baldazzi et al. (2008) studied this question.
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