Sch 31828, a novel antibiotic from a Microbispora sp. Taxonomy, fermentation, isolation and biological properties.

In the course of screening for novel antifungal antibiotics, a new solvent extractable antifungal, Sch 31828 (antibiotic EV22) was isolated from an unusual Microbispora sp. SCC 1438. Sch 31828 exhibited good in vitro activity against Candida albicans and dermatophytic fungi, and moderate activity against Staphylococcus aureus1^' 1. Microorganism The producing culture, SCC 1438, was iso-Recently Kempf et a/.2), Onishi et al.5\ and Lewis and Menes4) reported the isolation of a compound, L-660,631, from the culture broth of two unknown Actinomycetes species, the structure of L-660,631 is identical to Sch 31828. JUNE 1988 culture grows well from 27 to 40C on yeastglucose agar (yeast extract 1.0%, glucose 1.0%, Difco agar 1.5%, pH 7.0). Growth does not