What question did this study set out to answer?

To evaluate the relative contributions of aerobic and anaerobic gram-negative intestinal bacteria to endotoxin release in the mouse gut during oral antibiotic therapy.

January 1, 1986Scandinavian Journal of Infectious Diseases

Oral Administration of Antibiotics and Intestinal Flora Associated Endotoxin in Mice

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Authors

HGH GorisHanze University of Applied Sciences FBFroukje de BoerPhilips (Finland)DWD. van der WaaijLeiden University

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Implication

Animal experiment demonstrates selective elimination of aerobic gram-negative bacteria reduces fecal endotoxin by 90% in mice, indicating aerobic flora drive most gut endotoxin release.

Key Points

To evaluate the relative contributions of aerobic and anaerobic gram-negative intestinal bacteria to endotoxin release in the mouse gut during oral antibiotic therapy.
Administered nonabsorbable oral antibiotics (polymyxin, aztreonam, temocillin, or cephalothin/neomycin) to C3H/Law mice to selectively or completely decontaminate gut bacteria.
Measured endotoxin concentrations in fecal supernatants using the Limulus amebocyte lysate assay.
Selective elimination of aerobic gram-negative bacteria with polymyxin, aztreonam, or temocillin decreased fecal endotoxin concentrations to 10% of untreated control values.
Complete intestinal decontamination with cephalothin and neomycin reduced fecal endotoxin concentrations to 1% of control levels.
Intestinal aerobic gram-negative bacteria accounted for approximately 90% of total feces-derived endotoxin release in mice.

Cite This Study

Goris et al. (1986) studied this question.

synapsesocial.com/papers/6a8256e1a8461dff0846cb2b https://doi.org/10.3109/00365548609032307

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Implication

Animal experiment demonstrates selective elimination of aerobic gram-negative bacteria reduces fecal endotoxin by 90% in mice, indicating aerobic flora drive most gut endotoxin release.

Oral Administration of Antibiotics and Intestinal Flora Associated Endotoxin in Mice

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Implication

Key Points

Cite This Study

Oral Administration of Antibiotics and Intestinal Flora Associated Endotoxin in Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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