The versatile building block, methoxyallene reveals another a new facet: The titanium derivative 1 derived from it reacts with aldehydes at the γ position. Thus the methoxyalkynes anti-3 arise with high anti-selectivity on reaction of 1 with α-N,N-dibenzylamino aldehydes 2. These activated carboxylic acid derivatives can be transformed into the homostatine lactones anti-4 by hydrolysis. R CH3, CH2Ph, CH2CHMe2.
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Hormuth et al. (1993) studied this question.