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March 1, 1991Journal of VirologyOpen Access

Selection of an attenuated Coxsackievirus B3 variant, using a monoclonal antibody reactive to myocyte antigen

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Population

BALB/c mice and cultured HeLa cells and myocytes

Comparison

Infection with antibody-selected H3-10A1 variant… vs Infection with pathogenic variants CVB3W or H3

Design

Preclinical

Authors

NHNancy Van HoutenUniversity of North Carolina at Chapel HillPBPhilippe BouchardInsermAMAlbert MoraskaUniversity of Colorado Anschutz Medical Campus

Discussion

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Implication

Attenuated CVB3 escape mutant in mice; leaves open whether targeted variants could inform myocarditis vaccine research.

Structured PICO

P
Population
BALB/c mice and cultured HeLa cells and myocytes
I
Intervention
Infection with antibody-selected H3-10A1 variant of coxsackievirus B3 (10^6 PFU)
C
Comparator
Infection with pathogenic variants CVB3W or H3 (10^6 PFU)
O
Outcome
Animal mortalitysurrogate

An antibody-selected escape mutant of coxsackievirus B3 (H3-10A1) exhibits markedly reduced pathogenicity and myocarditis induction in a murine model.

Cite This Study

Houten et al. (1991) studied this question.

synapsesocial.com/papers/6a826158f10a9fcdd646cdd1https://doi.org/10.1128/jvi.65.3.1286-1290.1991
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