Why the study?
Can inhibitory enzyme-linked immunosorbent assay detect Aichi virus infection by measuring immunoglobulin responses in patients with gastroenteritis?
Can inhibitory enzyme-linked immunosorbent assay detect Aichi virus infection by measuring immunoglobulin responses in patients with gastroenteritis?
Inhibitory ELISA can effectively identify Aichi virus infection by detecting specific IgM, IgA, and IgG responses in patients with gastroenteritis.
Answers are grounded in this paper and cite their sources.
Supports inhibitory ELISA for Aichi virus detection in gastroenteritis; leaves open its diagnostic role pending prospective validation.
Using inhibitory enzyme-linked immunosorbent assay, seroconversions to Aichi virus were detected in 24 (42.9%) of 56 patients with gastroenteritis in six outbreaks. Virus-specific immunoglobulin M (IgM) was detected in convalescent-phase sera from 7 of 24 patients. Of the other 17 patients, 12 developed a significant increase in both IgA and IgG levels and 5 developed a significant increase in IgG alone.
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Yamashita et al. (2001) studied this question.
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