Huntington'S disease (HD) is an autosomal dominant disorder associated with neuronal degeneration especially involving the basal ganglia and cerebral cortex. The cardinal signs of dementia and involuntary movements usually appear in middle life. Although the pathogenesis of this disease remains unknown, its course progres sive, and the efficacy of available treatments limited, a recent surge of investigative interest has yielded significant information about HD and related central degenera tive disorders.
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Shoulson et al. (1975) studied this question.