Why the study?
Do prostacyclin analogues inhibit tissue factor expression in human monocytic cells?
Do prostacyclin analogues inhibit tissue factor expression in human monocytic cells?
Prostacyclin analogues downregulate tissue factor expression in monocytes via a cAMP-dependent mechanism, highlighting a potential antithrombotic pathway.
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May suggest antithrombotic potential for prostacyclin analogues; leaves open translation from animal models to human cells or practice.
Crutchley et al. (1992) studied this question.
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