Why the study?
Does midazolam pretreatment reduce propofol induction dose requirements in younger and older adults?
Population
120 patients: 60 younger patients (aged 18-35 years) and 60 older patients (aged over 60 years)
Comparison
Pretreatment with midazolam at two different… vs Placebo pretreatment plus 0.75 microg/kg of…
Design
RCT, randomised, double-blind
Authors
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Reduces propofol induction doses more in older adults; confirms age-dependent sparing without stability or apnoea gains.
Does midazolam pretreatment reduce propofol induction dose requirements in younger and older adults?
Midazolam pretreatment reduces propofol induction dose requirements, especially in older adults, but does not improve cardiovascular stability or reduce apnoea.
Cressey et al. (2001) studied this question.
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