Why the study?
Does Na+-K+ pump inhibition and subsequent Ca2+ elevation cause irreversible cell injury in cultured embryonic chick heart cells?
Population
Cultured embryonic chick heart cells
Comparison
Inhibition of the Na+-K+ pump for 1 hour vs Control solution
Design
Preclinical
Follow-up
6 hours
Authors
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Reversibility after Na+-K+ pump inhibition in chick cells indicates no irreversible injury; hypothesis-generating and should not yet inform clinical practice.
Does Na+-K+ pump inhibition and subsequent Ca2+ elevation cause irreversible cell injury in cultured embryonic chick heart cells?
Inhibition of the Na+-K+ pump and subsequent intracellular calcium elevation does not inherently cause irreversible myocardial cell injury in cultured embryonic chick heart cells.
Murphy et al. (1983) studied this question.
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