Gram-Negative Bacillary Meningitis

Letters and Corrections1 July 1982Gram-Negative Bacillary MeningitisSTEVEN L. BERK, M.D.STEVEN L. BERK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-1-145 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Drs.Rahal and Simberkoff (1) are to be commended for their detailed and objective discussion of antimicrobial therapy in adult gram-negative bacillary meningitis, a topic that has prompted unusually bitter debate among infectious disease specialists. Such debate about therapy is not unexpected for a disease that is relatively rare, involves a number of different bacterial species with variable antibiotic resistance patterns, has a different clinical presentation depending on the patient, and for which no controlled trials have ever been done. The debate, however, has been fueled by reports of dramatic success against gram-negative bacillary meningitis with third-generation cephalosporins...References1. RAHALSIMBERKOFF JM. Host defense and antimicrobial therapy in adult gram-negative bacillary meningitis. Ann Intern Med. 1982;96:468-74. LinkGoogle Scholar2. CHERUBINMARRSIERRABECKER EJMS. Listeria and gram-negative bacillary meningitis in New York City, 1972-1979. Frequent causes of meningitis in adults. Am J Med. 1981;71:199-209. CrossrefMedlineGoogle Scholar3. BERKMCCABE SW. Meningitis caused by gram-negative bacilli. Ann Intern Med. 1980;93:253-60. LinkGoogle Scholar4. MANGIQUINTILIANIANDRIOLE RRV. Gram-negative bacillary meningitis. Am J Med. 1975;59:829-36. CrossrefMedlineGoogle Scholar5. RAHAL J. Accumulated experience with moxalactam therapy of gram-negative bacillary meningitis. Rev Infect Dis. (In press.) Google Scholar6. KREGERCRAVENMCCABE BDW. Gram-negative bacteremia. IV. Re-evaluation of clinical features and treatment in 612 patients. Am J Med. 1980;68:344-55. CrossrefMedlineGoogle Scholar1. RAHALSIMBERKOFF JM. Host defense and antimicrobial therapy in adult gram-negative bacillary meningitis. Ann Intern Med. 1982;96:468-74. LinkGoogle Scholar2. TEELEDASHEFSKYRAKUSANKLEIN DBTJ. Meningitis after lumbar puncture in children with bacteremia. N Engl J Med. 1981;305:1079-81. CrossrefMedlineGoogle Scholar3. WALKER S. Meningitis after lumbar puncture in children with bacteremia [Utter]. N Engl J Med. 1982;306:608. CrossrefMedlineGoogle Scholar4. FEDER H. Meningitis after lumbar puncture in children with bacteremia [Utter]. N Engl J Med. 1982;306:608. CrossrefMedlineGoogle Scholar5. ONORATOWORMSERNICHOLAS IGP. 'Normal' CSF in bacterial meningitis. JAMA. 1980;244:1469-71. CrossrefMedlineGoogle Scholar6. ENGSELIGMAN RS. Lumbar puncture-induced meningitis. JAMA. 1981;245:1456-9. CrossrefMedlineGoogle Scholar1. RAHALSIMBERKOFF JM. Host defense and antimicrobial therapy in adult gram-negative bacillary meningitis. Ann Intern Med. 1982;96:468-74. LinkGoogle Scholar2. NAHATAPOWELL MD. Bioavailability and clearance of chloramphenicol after intravenous chloramphenicol succinate. Clin Pharmacol Ther. 1981;30:368-72. CrossrefMedlineGoogle Scholar3. SLAUGHTERPIEPERCERRABRODSKYKOUP RJFBJ. Chloramphenicol sodium succinate kinetics in critically ill patients. Clin Pharmacol Ther. 1980;28:69-77. CrossrefMedlineGoogle Scholar4. POWELLNAHATA DM. Chloramphenicol: new perspectives on an old drug. Drug Intell Clin Pharm. 1982;16:295-300. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1982Volume 97, Issue 1Page: 145-147KeywordsAntibiotic resistanceAntimicrobialsBacterial diseasesClinical trialsInfectious diseasesMeningitis Issue Published: 1 July 1982 PDF downloadLoading ...