A Practical Synthesis of Ureas from Phenyl Carbamates

All articles of this category Using DMSO as solvent, a mild and efficient procedure for the synthesis of unsymmetrical N,N' -disubstituted ureas from phenyl carbamates is described. The carbamates are treated with a stoichiometric amount of amine at ambient temperature, generating the ureas in high yield and high purity. The reaction is mild, fast, and easily scaled up. phenyl carbamates - unsymmetrical ureas - mild conditions - DMSO as solvent