Purpose: Diabetes profoundly and negatively impacts all domains of fe-male sexual function, however, the underlying pathophysiological mecha-nisms remain unknown. To date, limited studies have been published on the effects of type 1 & type 2 diabetes on female genital sexual arousal and how this may impact overall sexual function. The aim of this review is to discuss the effects of diabetes on female sexual function and insights from laboratory studies on the underlying pathophysiology. Materials and Methods: Using PubMed, we reviewed and evaluated the literature published between 1970 and 2009 and data from our laboratories and others investigating the effects of type 1 and type 2 diabetes on genital sexual arousal responses. Results: Women with diabetes experience diminished genital arousal, re-duced vaginal lubrication, vaginal atrophy, dyspareunia, and increased vaginal infections. Also, a number of studies using type 1 and type 2 dia-betic animal models have reported reduced plasma estradiol levels and
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Traish et al. (2009) studied this question.
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