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Enzyme secretion from incubated guinea pig submandibular gland slices was induced by adrenaline, noradrenaline, dopamine, 5‐hydroxytryptamine or dibutyryl cyclic AMP combined with theophylline. Effects of alpha‐ and beta‐blocking agents on stimulated peroxidase and amylase discharge were studied. Propranolol (beta‐blocker), but not phenoxybenzamine (alpha‐blocker), markedly inhibited the secretion of both enzymes induced by adrenaline or noradrenaline. Dopamine and 5‐hydroxytryptamine were found to be potent enzyme secretagogues. Both propranolol and phenoxybenzamine antagonized the effects of these two amines. The secretagogic effect of dibutyryl cyclic AMP in combination with theophylline was not affected by either propranolol or phenoxybenzamine. L‐DOPA and 5‐hydroxytryptophan were without effect on enzyme secretion. It is concluded that peroxidase and amylase are secreted in parallel from guinea pig submandibular gland and that enzyme release is mainly mediated via the beta‐adrenergic receptor.
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Carlsöö et al. (1974) studied this question.
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