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Review highlights renal membrane transporter roles in drug elimination and toxicity, indicating their clinical significance as drug targets and sources of adverse interactions.
The kidney functions not only as a metabolite elimination organ but also plays an important role in pharmacotherapy. The kidney tubule epithelia cells express membrane carriers and transporters, which play an important role in drug elimination, and can determine drug nephrotoxicity and drug-drug interactions, as well as constituting direct drug targets. The above aspects of kidney transport proteins are discussed in the review.
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Łapczuk-Romańska et al. (2023) studied this question.
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