Design
Network pharmacology study
Key result
Network pharmacology analysis identified 47 candidate targets at the intersection of heart failure and gut metabolites, with PPARG as the hub target with the most extensive connections.
Authors
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Suggests gut metabolite targets in HF; hypothesis-generating and requires experimental validation before clinical consideration.
This network pharmacology study identifies key genes and pathways linking gut microbiota metabolites to heart failure, providing targets for future experimental research.
Tan et al. (2026) studied Heart failure. Gut microbiota-derived metabolites was evaluated on Overlapping targets of heart failure and gut metabolites. Network pharmacology analysis identified 47 candidate targets at the intersection of heart failure and gut metabolites, with PPARG as the hub target with the most extensive connections.