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The master of ceremonies! MC2050, a new water-soluble quinazoline-based PARP-1 inhibitor, exerts a cytoprotective effect against oxidative stress in SH-SY5Y neuroblastoma cells by abolishing the toxic effect of H2O2 and counteracting PARP-1 overactivation. Moreover, pretreatment of lytic-cycle-induced Raji cells with MC2050 leads to the modulation of EBNA1 protein expression.
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Mosca et al. (2011) studied this question.
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