What does this research mean for the field?

Intermittent ascending aortic balloon occlusion during closed-chest CPR significantly increases coronary perfusion pressure, resuscitation success, and 48-hour survival after prolonged cardiac arrest. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate whether intermittent ascending aortic balloon occlusion, alone or combined with proximal aortic infusion, improves coronary perfusion pressure, resuscitation success, and 48-hour survival after prolonged cardiac arrest.

August 17, 2026CirculationOpen Access

Augmented efficacy of external CPR by intermittent occlusion of the ascending aorta.

Q: What are the key findings of this study?

Intermittent ascending aortic balloon occlusion during CPR resulted in 100% 48-hour survival in pigs after prolonged cardiac arrest, compared to 10% with conventional methods (P<0.05).

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Cardiac arrest (ventricular fibrillation) (n=20). Intervention: Intermittent ascending aortic balloon occlusion vs. Epinephrine with or without proximal aortic infusion. Primary outcome: 48-hour survival (p=<0.05).

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Key result

Intermittent aortic balloon occlusion boosts 48-hour post-arrest survival to 100% vs. standard CPR in swine.

P<0.05
n=20

Why the study?

Does intermittent ascending aortic balloon occlusion improve resuscitability and 48-hour survival in a porcine model of prolonged cardiac arrest?

Population

20 anesthetized, mechanically ventilated, normovolemic domestic pigs subjected to 7 minutes of untreated…

Comparison

Intermittent ascending aortic balloon occlusion… vs Precordial compression with epinephrine…

Design

Preclinical, Randomized to one of four groups

Follow-up

48 hours

Authors

WTWenjun TangHainan Medical University MWMax Harry WeilCross-Cutting Cardiology MNM NocUniversity of Trieste

Discussion

Member takes

Implication

Intermittent ascending aortic balloon occlusion during CPR significantly increases coronary perfusion pressure and 48-hour survival in a porcine model of prolonged cardiac arrest.

Key Points

To evaluate whether intermittent ascending aortic balloon occlusion, alone or combined with proximal aortic infusion, improves coronary perfusion pressure, resuscitation success, and 48-hour survival after prolonged cardiac arrest.
Twenty domestic pigs (N=20) were anesthetized, mechanically ventilated, and subjected to 7 minutes of untreated ventricular fibrillation prior to precordial compression.
Animals were randomized to four intervention arms: (1) aortic balloon occlusion with proximal oxygenated saline infusion, (2) balloon occlusion alone, (3) proximal infusion with epinephrine, or (4) epinephrine alone.
Balloon occlusion was applied for 30 seconds during each minute of CPR, with defibrillation attempts initiated at 1 minute of CPR and repeated every minute until return of spontaneous circulation or 30 minutes elapsed.
Aortic balloon occlusion significantly augmented coronary perfusion pressure generated by closed-chest precordial compression.
All 10 animals across both balloon occlusion groups (10/10, 100%) were successfully resuscitated and achieved 48-hour survival.
In the non-occlusion cohorts, 3 of 5 animals (60%) receiving infusion plus epinephrine were resuscitated but 0 of 5 (0%) survived 48 hours (P = .02 vs occlusion), while only 1 of 5 animals (20%) receiving epinephrine alone achieved resuscitation and 48-hour survival (P < .05).

Study Design

Type

RCT (n=20)

Randomization

Randomized to one of four groups

Structured PICO

Does intermittent ascending aortic balloon occlusion improve resuscitability and 48-hour survival in a porcine model of prolonged cardiac arrest?

Population

20 anesthetized domestic pigs with induced ventricular fibrillation subjected to 7 minutes of untreated cardiac arrest before resuscitation.

Intervention

Intermittent ascending aortic balloon occlusion (inflated for 30 seconds during each minute of cardiopulmonary resuscitation) with or without proximal infusion of oxygenated saline.

Comparator

Precordial compression with epinephrine injection (with or without proximal aortic infusion) in the absence of balloon occlusion.

Outcome

Resuscitability (return of spontaneous circulation) and 48-hour survival.hard clinical

Main Result

Absolute Event Rate: 100% vs 10%

p-value: p=<0.05

Intermittent ascending aortic balloon occlusion during CPR significantly increases coronary perfusion pressure and 48-hour survival in a porcine model of prolonged cardiac arrest.

Cite This Study

Tang et al. (1993) conducted an RCT in Cardiac arrest (ventricular fibrillation) (n=20). Intermittent ascending aortic balloon occlusion vs. Epinephrine with or without proximal aortic infusion was evaluated on 48-hour survival (p=<0.05). Intermittent ascending aortic balloon occlusion during CPR resulted in 100% 48-hour survival in pigs after prolonged cardiac arrest, compared to 10% with conventional methods (P<0.05).

synapsesocial.com/papers/6a827da9bfd4574fc2c8353e https://doi.org/10.1161/01.cir.88.4.1916

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Implication

Intermittent ascending aortic balloon occlusion during CPR significantly increases coronary perfusion pressure and 48-hour survival in a porcine model of prolonged cardiac arrest.

Augmented efficacy of external CPR by intermittent occlusion of the ascending aorta.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Augmented efficacy of external CPR by intermittent occlusion of the ascending aorta.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider