Extensive experimentation in animals has demonstrated that the sex hormones very definitely effect certain non-sex organs of their bodies. Ratschow and Kosterman (1), using androgens experimentally in rats, report an absence of sloughing following severe vasoconstriction by ergotamine. Korenchevsky (2) and his coworkers report changes in weight and in histologic structure in rat livers and hearts following administration of androsterone or testosterone esters to the animals, attributing certain hepatotrophic and cardiotrophic properties to these hormones. That these hormones also exert nephny trophic effects was reported in an earlier paper by the same authors. Therapeutic applicability of these properties suggests itself in disorders of these organs in human beings and it is the purpose of this report to describe the results of such treatment in suitable cases of angina pectoris and of angina of effort.1 The effect of testosterone on the human cardiovascular system has been the subject of but few reports in the literature thus far.
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Lynne Hamm (1942) studied this question.