Nanofibrous scaffolds of poly(lactide-co-caprolactone) and poly(ethyl oxazoline) demonstrate suitable mechanical properties and biocompatibility for cardiac tissue engineering.
Supports preclinical cardiac scaffold development; leaves open human translation pending in vivo validation.
AIM: The aim of the study is to develop scaffolds that mimic native tissue properties for effective regeneration of the myocardium, which is affected by the gradual thinning of left ventricular tissue after an infarction. MATERIALS & METHODS: Heterogenous nanofibrous scaffolds made of poly(lactide-co-caprolactone) and poly(ethyl oxazoline) were characterized for physico-chemical properties. The biocompatibility of the scaffolds was evaluated by studying the adhesion, proliferation and differentiation of H9c2 cells. RESULTS: The scaffolds mimic the cardiac extracellular matrix and showed enhanced tensile strength, improved cell compatibility along with the expression of cardiac marker proteins. CONCLUSION: Our experimental data confirmed the importance of native tissue architecture and mechanical strength for improved cell response in cardiac tissue engineering.
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Lakshmanan et al. (2015) studied this question.
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