The synthesis of poly( β ‐alanine) by Candida antarctica lipase B immobilized as novozyme 435 catalyzed ring‐opening of 2‐azetidinone is reported. After removal of cyclic side products and low molecular weight species pure linear poly( β ‐alanine) is obtained. The formation of the polymer is confirmed with 1 H NMR spectroscopy and MALDI‐TOF mass spectrometry. The average degree of polymerization of the obtained polymer is limited to DP̄ = 8 by its solubility in the reaction medium. Control experiments with β ‐alanine as a substrate confirmed that the ring structure of the 2‐azetidinone is necessary to obtain the polymer. magnified image
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Schwab et al. (2008) studied this question.
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