Two-liquid phase biocatalytic reactors in which a large proportion of the reaction volume is occupied by the organic phase have been investigated for steroid transformations and the modification of oils and fats. The organic phase may consist of the reactant alone or the reactant dissolved in a water-immiscible organic solvent. Under appropriate conditions, immobilized cells and enzymes have reasonable operational stabilities in such reactors, and some commercial processes are being developed.
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M. D. Lilly (1983) studied this question.
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