Presence of a glucuronic acid-containing carbohydrate unit in human thyroglobulin.

Human thyroglobulin, isolated either by salt fractionation from pooled thyroids or by gel filtration from individual glands, has been found to contain glucuronic acid.This is in contrast to the thyroglobulins of calf, sheep, pig, and guinea pig, from which this sugar is absent.That glucuronic acid is an integral component of human thyroglobulin was demonstrated by its continued association with the protein during ion exchange chromatography on DEAE-cellulose and gel filtration in sodium dodecyl sulfate after