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March 1, 1992British Journal of PharmacologyOpen Access

Effects of BRL 38227 on potassium currents in smooth muscle cells isolated from rabbit portal vein and human mesenteric artery

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Population

Single smooth muscle cells isolated from the rabbit portal vein and the human mesenteric artery

Comparison

BRL 38227 (0.03-10 microM) vs Baseline/control conditions without BRL 38227

Design

Preclinical

Authors

SRScott N. RussellUniversity of Nevada, RenoSSSmirnov SvRutgers, The State University of New JerseyPAPhilip I. AaronsonKing's College London

Discussion

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Overview

BRL 38227 activates vascular KATP channels in animal cells; leaves open translation to human cardiovascular therapy.

Structured PICO

P
Population
Single smooth muscle cells isolated from the rabbit portal vein and the human mesenteric artery
I
Intervention
BRL 38227 (0.03-10 microM)
C
Comparator
Baseline/control conditions without BRL 38227
O
Outcome
Potassium currents measured by whole cell voltage clamp techniquesurrogate

BRL 38227 activates a potassium conductance with electrophysiological and pharmacological characteristics of ATP-sensitive K+ channels in vascular smooth muscle cells.

Cite This Study

Russell et al. (1992) studied this question.

synapsesocial.com/papers/6a8289705bcab2ccdb8d5a64https://doi.org/10.1111/j.1476-5381.1992.tb09017.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanisms of vasodilatation induced by potassium-channel activators1991 · 32 citations
  2. 2Properties of the cromakalim‐induced potassium conductance in smooth muscle cells isolated from the rabbit portal vein1989 · 129 citations
  3. 3Extracellular Ca2+‐activated K channel in coronary artery smooth muscle cells and its role in vasodilation1989 · 45 citations
  4. 4Hyperpolarizing Vasodilators Activate ATP-sensitive K + Channels in Arterial Smooth Muscle1989 · 1,197 citations
  5. 5Spontaneous transient outward currents in single visceral and vascular smooth muscle cells of the rabbit.1986 · 459 citations