Why the study?
Methods are needed to overcome the morphine-related delay in absorption and onset of action of oral P2Y12 inhibitors in acute coronary syndrome.
Does metoclopramide co-administration improve the pharmacokinetics and pharmacodynamics of ticagrelor in patients with unstable angina treated with morphine?
Population
Patients presenting with unstable angina and treated with morphine
Comparison
Metoclopramide co-administration vs metoclopramide-naive
Design
Trial
Follow-up
6 hours
Authors
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May enhance early ticagrelor exposure in morphine-treated unstable angina; leaves open effects on clinical outcomes.
Does metoclopramide co-administration improve the pharmacokinetics and pharmacodynamics of ticagrelor in patients with unstable angina treated with morphine?
Co-administration of metoclopramide improves the pharmacokinetic and pharmacodynamic profile of ticagrelor in patients with unstable angina treated with morphine.
Sikora et al. (2018) studied this question.
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