High Resolution Image Download MS PowerPoint Slide The first asymmetric silylation of unsaturated lactams and amides using Cu(I)–NHC catalysts and PhMe 2 SiBpin has been accomplished. The method has been exploited in an expedient asymmetric synthesis of the ( R )-enantiomer of the nootropic drug oxiracetam.
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Pace et al. (2013) studied this question.
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